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Pancreapedia Reviews

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Biology and Physiology

Section Editors  Fred Gorelick and John Williams

  • Anatomy and Histology of the Pancreas - Daniel S. Longnecker, Dartmouth University
  • Development of the Pancreas - Chris Pin, University of Western Ontario
  • Receptors for Secretagogues and other Regulatory Molecules - Robert T. Jensen, NIH
  • Lipid Molecules as Structural and Regulatory Components of Acinar Cells
  • Bioenergetics of Exocrine Pancreas
  • Regulation of intracellular Calcium in Pancreatic Acinar Cells - David I Yule, University of Rochester
  • Intracellular Pathways for Digestive Enzyme synthesis and Secretion
  • Regulation of Physiologic and Pathologic Exocytosis in Pancreatic Acinar Cells - Subhankar Dolai, Tao Liang, Laura I. Cosen-Binker,Patrick P.L. Lam  Y Gaisano, University of Toronto
  • The acinar cell cytoskeleton and its role in secretion
  • Role of ion channels and transporters in zymogen granule function - Frank Thevenod, University of Witten/Herdecke, Germany
  • The fusion Pore as Viewed by Atomic Force Microscopy - Bhanu Jena, Wayne State University
  • Electrophysiology of Acinar Cells
  • The Role of Cyclic AMP in Acinar and Duct Cell Function
  • The Golgi Apparatus and its Function in Acinar Cells
  • Biosynthesis and Structure of Zymogen Granules
  • Regulation of Pancreatic Gene Expression in response to Diet and Hormones
  • Pancreatic Digestive Enzyme Synthesis and its Translational Control
  • Regulation of Normal and Adaptive Pancreatic Growth - John A Williams, University of Michigan
  • Regeneration of the Pancreas - Hiroshi Saito and Mark Evers, University of Kentucky
  • Pancreatic Proteases and Protein Digestion
  • Pancreatic Lipases and Fat Digestion
  • Pancreatic Amylase and Carbohydrate Digestion
  • Hormonal Regulation of Pancreatic Secretion - Rashmi Chandra and Rodger Liddle, Duke University
  • Neural Control of the Pancreas - Alberto Travagli, Penn State College of Medicine
  • Structure of the Islets and Vascular Relationship to the Exocrine Pancreas
  • Secretion of insulin in Response to Diet and Hormones
  • Regulation of Pancreatic Exocrine Function by Islet Hormones
  • Human Pancreatic Enzyme Secretion
  • Regulation of Pancreatic Fluid and Electrolyte Secretion
  • Molecular Mechanisms of Pancreatic Bicarbonate Secretion
  • Structure function relationships of CFTR in health and disease - Patrick Thibodeau, University of Pittsburgh
  • Pancreatic Stellate Cells: Function and Regulation
  • The Vascular Supply of the Pancreas and the Regulation of Pancreatic Blood Flow - Jens Werner, University of Heidelberg

Experimental Models of Disease

PANCREATITIS Section Editors Stephen Pandol and Ashok Saluja

  • In Vitro Models of Pancreatis
  • Commonly Employed Rodent Models of Experimental Acute Pancreatitis: Their Strengths and Weaknesses, Relevance to Human Disease, Selection, and Appropriate Use - Peter Hegyi, George Perides, Michael Steer and Zoltan Rakonczay
  • Pathophysiology of Calcium Signaling in the Acinar Cell and its Role in Pancreatitis
  • The Role of Trypsin Activation in the Genesis of Experimental Pancreatitis
  • The Role of Cytokines and inflammation in the genesis of Experimental Pancreatitis
  • Models for induction of Chronic Pancreatitis and Fibrosis - Fred Gorelick, Yale University
  • Heat Shock Proteins as Modulators of Pancreatitis
  • The Role of ER Stress in the Genesis of Pancreatitis
  • Spontaneous Pancreatitis in Genetically Modified Animal Strains
  • Mechanism of Pancreatic Pain in Animal Models
  • The effects of bile acids on pancreatic ductal cells - Viktoria Venglovecz, Zoltan Rakonczay Jr. and Peter Hegyi, University of Szeged
  • Obesity. lipids and pancreatitis - Vijay Singh, University of Pittsburgh
  • Effects of tobacco smoke on the pancreas - Edward Thrower, Yale University

MODELS OF PANCREATIC INHERITED DISEASE

  • Transgenic animal modes as model systems for inherited diseases of the pancreas
  • Transgenic pigs, mice and ferrets as models for Cystic Fibrosis - Alyce Uc, University of Iowa
  • Recombinant proteins as model systems for inherited disease of the pancreas

PANCREATIC NEOPLASIA  Section Editor Craig Logsdon

  • In vitro pancreatic cancer models using cell lines and primary isolates
  • Human tumor cell transfer in vivo to study pancreatic cancer
  • Mouse genetic models of pancreatic cancer: the role of Ras
  • Role of pancreatic cancer stem cells in tumor formation
  • Mechanisms of metastasis of pancreatic cancer
  • Role of Pancreatic Stellate Cells in Promoting Neoplasia
  • Testing of new therapeutic agents in Animal Models

IMAGING AND VISUALIZATION OF THE PANCREAS IN ANIMAL MODELS

  • Non-invasive imaging using molecular probes
  • Pancreas imaging by small animal CT and MRI

ENDOCRINE-EXOCRINE INTERACTIONS

  • Effects of Diabetes on the Exocrine Pancreas
  • Effects of Exocrine Pancreatic Disease on the Islets

DISEASES OF THE PANCREAS

ACUTE PANCREATITIS  Section Editor Markus Lerch and Marc Basselink

  • Biliary Stone Induced Acute Pancreatitis
  • Alcohol Induced Pancreatitis
  • Drug Related acute Pancreatitis
  • Diagnosis and Classification of Acute Pancreatitis
  • Modalities of Treatment
  • Diagnosis and management of pseudocysts and fistulas
  • Pancreatic Abcess
  • Role of Enteral and Parenteral Nutrition
  • Surgical Management of necrotizing Pancreatitis
  • Relationship between Obesity and Pancreatitis

AUTOIMMUNE PANCREATITIS Section Editor Suresh Chari     

  • Pathology and Diagnosis of Autoimmune Pancreatitis
  • Therapy of Autoimmune Pancreatitis

CHRONIC PANCREATITIS  Section Editors Julia Mayerle and Pramod Garg

  • Epidemiology of Chronic Pancreatitis
  • Pathogenesis of Chronic Pancreatits
  • Pancreatic Fibrosis
  • Role of Duct Cells in the Pathogenesis of Chronic Pancreatitis
  • Alcohol, Smoking and Chronic Pancreatitis
  • Natural History of Chronic Pancreatitis
  • Recurrent Acute Pancreatitis and Progression to Chronic Pancreatitis
  • Clinical and Laboratory Diagnosis of Chronic Pancreatitis
  • Hereditary Pancreatitis
  • Idiopathic Chronic Pancreatitis: Worldwide Spectrum and Genetic Predisposition
  • Clinical Implications of Genetic Testing and counseling for Hereditary and Idiopathic pancreatitis
  • Pathogenesis of Pancreatic Pain in Chronic Pancreatitis
  • Staging Chronic Pancreatitis: Duct Morphology and Quantification of Fibrosis and Pancreatic Function
  • Imaging of Chronic Pancreatitis
  • Medical Therapy for Chronic Pancreatitis: Diet, Enzymes and Analgesics
  • Antioxidants in Chronic Pancreatitis
  • Diagnosis and Treatment of Pancreatic Insufficiency with Digestive Enzymes
  • Interventional and Endoscopic Therapy of Chronic Pancreatitis
  • Surgery in Chronic Pancreatitis
  • Total Pancreatectomy and Islet Transplantation
  • Management of Endocrine Failure in Chronic Pancreatitis
  • Surveillance for Pancreatic Cancer in Chronic Pancreatitis:Clinical Relevance and Cost Effectiveness
  • Pharmaceutical Development for Chronic Pancreatitis: Piplelines and Future Options
  • Co-morbidity and Complications of Chronic Pancreatitis hampering Treatment

PANCREATIC ADENOCARCINOMA

  • Identifying Biomarkers to Diagnose and Follow Pancreatic Cancer
  • Imaging Techniques to Diagnose Pancreatic Cancer
  • Epidemiology of Pancreatic Cancer
  • Pathology of Exocrine Pancreatic Tumors
  • Surgical Treatment of Pancreatic Cancer
  • Primary Chemotherapy
  • The Role of aduvant therapy for Pancreatic Cancer

OTHER PANCREATIC NEOPLASMS  Section Editor Carlos Fernandez Del Castillo

  • Cystic Neoplasms of the Pancreas
  • Mucinous Cystic Neoplasms
  • Neuroendocrine Tumors of the Pancreas

DIABETES AND OBESITY  Section Editor Dana Andersen

  • Alterations in Exocrine Pancreatic Function in Diabetes
  • Diabetes That Results from Chronic Pancreatitis
  • Diabetes as a Risk Factor for Pancreatic Cancer
  • Obesity and its Effect on Pancreatic Disease

HEREDITARY DISEASES OF THE PANCREAS Section Editors David Whitcomb and Mark Lowe

  • Cystic Fibrosis
  • Shwachman Diamond Syndrome
  • Hereditary Pancreatitis
  • Familial Pancreatic Cancer
  • Testing for genetic risk factors

 

 

Older Reviews from Outside Sources

Our aim is to link to or reproduce chapters from prior editions of books where possible that contain useful material and references but are no longer in print or provide links to older review articles that are open access.

Chapters from The Pancreas, Biology, Pathobiology and Disease, Ed VLW Go et al, 1993