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Pathways

This section presents diagrams for pathways present in exocrine pancreatic cells. Although components known to be present in cells in general may be included to make a complete pathway, the emphasis is on components that have been studied in pancreatic acinar, ductal and stellate cells as well as the pathway initiators and effectors. Each pathway may have associated short Reviews, Molecules and Methods. One aim of this section is to help generate a molecular parts list and interaction diagram that describe pancreatic cells. Community members who establish the presence of specific molecules or isoforms are encouraged to contribute to the Pancreapedia.

Signaling Pathways

  1. Calcium mobilization by IP3, cADPR, NAADP
  2. DAG - PKC
  3. Calcium - calcineurin - NFAT
  4. Calcium - calmodulin - CaM kinases
  5. cAMP - PKA, Epac - Rap1
  6. PI3K - Akt - mTOR - S6K
  7. ERK Signaling
  8. SEK - JNK
  9. p38MAPK - MAPKAPK2
  10. Galpha12/13 - RhoA
  11. TGFbeta - SMAD
  12. EGFR and other TyrK Mediated Growth Factor Receptors
  13. Insulin and IGF signaling
  14. Src - FAK
  15. NF-κB Signaling
  16. Notch signaling
  17. HEDGEHOG SIGNALING
  18. Hippo Signaling

Functional Pathways

  1. Neural control of pancreatic function
  2. Hormonal Control of Pancreatic Function
  3. Acinar cell digestive enzyme secretion
  4. Duct cell electrolyte secretion
  5. Differentiation of pancreatic cell types
  6. Adaptive pancreatic growth
  7. Regulation of digestive enzyme (protein) translation

Pathophysiological Pathways

  1. Cell death pathways
  2. ER stress
  3. Induction of autophagy
  4. Premature activation of trypsin and pancreatitis
  5. Acinar-ductal metaplasia and the origin of panins
  6. Effects of CFTR mutation on the pancreas
  7. Activation of stellate cells and the induction of fibrosis
  8. Pancreatic Pain

Newest Pathways

Title Post date Pathway Type Author
EGFR and other TyrK Mediated Growth Factor Receptors April 18, 2013 Signaling John A. Williams
Diacylglycerol-PKC March 21, 2013 Signaling John A. Williams
Calcium mobilization by IP3, cADPR, NAADP March 15, 2013 Signaling David Yule
Hippo Signaling February 18, 2013 Signaling John A. Williams
Pathophysiological Pathways June 20, 2012 Signaling Pancreapedia Staff
Hormonal Control of Pancreatic Function June 19, 2012 Functional John A. Williams
Pancreatic Pain June 19, 2012 Pathophysiological John A. Williams
Regulation of NF-kappaB Activation April 9, 2012 Signaling John A. Williams
Activation of stellate cells and the induction of fibrosis March 14, 2012 Pathophysiological John A. Williams
Acinar cell digestive enzyme secretion January 26, 2012 Functional John A. Williams