My research work focuses on the interface of cell signalling and physiology of secretory epithelial cells.

Investigation of downstream events of the calcium signalling cascade is the major current research line of my laboratory. We are investigating links between calcium signalling and mitochondrial metabolism, activation and translocation of calcium binding proteins, calcium-dependent gene expression and role of calcium in programmed cell death (apoptosis). We are intersted in the role of calcium and calcium binding proteins in the development and progression of pancreatic cancer. The role of calcium ions in triggering the important disease acute pancreatitis is another focus of our research work.

I have also retained interest in fundamental mechanisms of calcium signalling, particularly with regards to organellar calcium handling (in nucleus, lumen of endoplasmic reticulum, endosomes and in mitochondria), calcium extrusion and calcium buffering. This analytical work is carried out in both exocrine secretory cells and neurons. We are also studying the mechanisms that are involved in establishing the resting calcium level (calcium leak from the internal stores, calcium influx and activity of calcium pumps at close to resting calcium levels).

Our research group has a strong technical background. One of the important activities of our research group is the development of optical techniques for cell physiology. We are testing new optical equipment and developing new applications for imaging, confocal and two photon systems.