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The Exocrine Pancreas: Current Concepts of Health and Disease
Instructions for reviews
Biology and Physiology Section Editors Fred Gorelick and John A Williams
Anatomy and Histology of the Pancreas - Daniel S. Longnecker, Dartmouth University Development of the Pancreas - Chris Pin, University of Western Ontario
Receptors for Secretagogues and other Regulatory Molecules
Bioenergetics of Exocrine Pancreas
Ca2+ Signaling in Pancreatic Acinar Cells - David I Yule, University of Rochester Intracellular Pathways for Digestive Enzyme synthesis and Secretion - Guy Groblewski, University of Wisconsin
Regulation of Physiologic and Pathologic Exocytosis in Pancreatic Acinar Cells - Subhankar Dolai, Tao Liang, Laura I. Cosen-Binker,Patrick P.L. Lam Y Gaisano, University of Toronto Role of the actin cytoskeleton in acinar cell protein secretion - Robert De Lisle, University of KansasChannels and Transporters in Zymogen Granule Membranes and their Role in Granule Function: Recent Progress and a Critical Assessment - Frank Thevenod, University of Witten/Herdecke, Germany The Secretory Portal - Porosome in Pancreatic Acinar Cells - Bhanu Jena, Wayne State University Ion Channels in Pancreatic Acinar Cells
Cyclic Nucleotides as Mediators Of Acinar and Ductal Function - Maria Eugenia Sabatini, Georgia Regents University Biosynthesis and Structure of Zymogen Granules - Xuequn Chen
Regulation of Pancreatic Gene Expression in response to Diet and Hormones
Pancreatic Digestive Enzyme Synthesis and its Translational Control
Regulation of Normal and Adaptive Pancreatic Growth - John A Williams, University of Michigan Pancreatic Regeneration Models, Mechanisms, and Inconsistencies - Farzad Esni, University of Pittsburgh Pancreatic Proteases and Protein Digestion
Pancreatic Lipases and Fat Digestion - Frederic Carriere, CNRS, Marseille
Pancreatic Amylase and Carbohydrate Digestion
Regulation of Pancreatic Secretion - Rashmi Chandra and Rodger Liddle, Duke University Neural Control of the Pancreas - Tanja Babic and Alberto Travagli, Penn State College of Medicine Structure of the Islets and Vascular Relationship to the Exocrine Pancreas
Secretion of Insulin in Response to Diet and Hormones - Elizabeth Mann and Melena Bellin, University of Minnesota Regulation of Pancreatic Exocrine Function by Islet Hormones
Secretion of the Human Exocrine Pancreas in Health and Disease - Philip A Hart and Darwin L Conwell, Ohio State University
Regulation of Pancreatic Fluid and Electrolyte Secretion - Hiroshi Ishiguro, Satoro Naruse and Martin Steward
Molecular Mechanisms of Pancreatic Bicarbonate Secretion - Min Goo Lee and Shmeul Muallem Pancreatic Duct Cell Electrophysiology
Structure function relationships of CFTR in health and disease - Patrick Thibodeau, University of Pittsburgh
Pancreatic Stellate Cells: Characterization, Isolation and role in ECM secretion - Minoti Apte group, University of New South Wales
Signaling pathways in Pancreatic Stellate Cells - Tooru Shimesegawa group, Sendai University
The Vascular Supply of the Pancreas and the Regulation of Pancreatic Blood Flow - Jens Werner, University of Heidelberg
Experimental Models of Disease PANCREATITIS Section Editors Stephen Pandol and Ashok Saluja
Experimental Acute Pancreatitis: In Vitro Models - Olga Mareninova, Abrahim Orabi and Sohail Husain, UCLA and University of Pittsburgh Commonly Employed Rodent Models of Experimental Acute Pancreatitis: Their Strengths and Weaknesses, Relevance to Human Disease, Selection, and Appropriate Use - Peter Hegyi, George Perides, Michael Steer and Zoltan Rakoncza, University of Szeged & Tufts Medical Center, Boston Calcium Signaling, mitochondria and acute pancreatitis: avenues for therapy - Li Wen, Rajarshi Mukherjee, Wei Huang and Robert Sutton, University of Liverpool Role of trypsinogen activation in genesis of experimental pancreatitis - Ajay Dixit, Rajinder Dawra, Vikas Dudeja and Ashok K.Saluja, University of Miami, FL Role of cytokines and inflammation in the genesis of experimental pancreatitis - Peter Szatmary and Ilya Gukovsky, University of Liverpool and UCLA Animal Models of Chronic Pancreatitis - Anamika Reed and Fred Gorelick, Yale University Immune Modulation in Acute and Chronic Pancreatitis - Aida Habtezion and Hana Algul, Stanford University and Munich Heat Shock Proteins as Modulators of Pancreatitis - Rajinder K. Dawra, Vikas Dudeja and Ashok K. Saluja, University of Miami Autophagy and the Endolysosomal System in Pancreatitis - Anna Gukovskaya, UCLA and Maria Vacarro, University of Buenos Aires
Endoplasmic Reticulum Stress and the Unfolded Protein Response in Exocrine Pancreas Physiology and Pancreatitis - Richard Waldron, Stephen Pandol, Aurelia Lugea and Guy Groblewski, Cedars Sinai Medical Center, UCLA and University of Wisconsin Spontaneous Pancreatitis in Genetically Modified Animal Strains - Yan Bi and Baoan Ji, Mayo Clinic, Jacksonville FL Pathogenesis of Pain in Chronic Pancreatitis - Dana Dominguez and Kimberly Kirkwood, UCSF The effects of bile acids on pancreatic ductal cells - Viktoria Venglovecz, Zoltan Rakonczay Jr. and Peter Hegyi, University of Szeged Alcohol and the Pancreas - Minoti V. Apte, Romano Pirola and Jeremy S. Wilson, University of New South Wales, Australia Effects of alcohol on pancreatic ductal function - Jozsef Maleth, Zoltan Rakonczay, Viktoria Venglovecz and Peter Hegyi, University of Szeged Smoking induced pancreatitis and pancreatic cancer - Mouad Edderkaoui, Cedars Sinai Medical Center and Edward Thrower, Yale University Experimental acute pancreatitis models relevant to lipids and obesity - Krutika S. Patel and Vijay P. Singh, Mayo Clinic Scottsdale, AZ
MODELS OF PANCREATIC INHERITED DISEASE
Transgenic animal modes as model systems for inherited diseases of the pancreas
Transgenic pigs, mice and ferrets as models for Cystic Fibrosis - Alyce Uc, University of Iowa
Recombinant proteins as model systems for inherited disease of the pancreas
Models of Diabetes and their effects on the Exocrine Pancreas
PANCREATIC NEOPLASIA Section Editors Craig Logsdon and Howard Crawford
Early detection biomarkers for pancreatic ductal adenocarcinoma
Neo adjuvant therapy for pancreatic ductal adenocarcinoma
Gemcitabine resistance mechanisms in pancreatic ductal adenocarcinoma
Future therapeutics for pancreatic ductal adenocarcinoma
Frontiers in pancreatic ductal carcinoma imaging - Kim Kelly, University of Virginia
Pancreas imaging by small animal CT and MRI
New approaches to targeting mutant KRas
Ras activity as the key to prevention of pancreatic adenocarcinoma - Craig Logsdon and Zobeida Cruz-Monserrate, MD Anderson Cancer Center
Pancreatic ductal adenocarcinoma stroma
Mouse models of pancreatic ductal adenocarcinoma
Role of pancreatic cancer stem cells in tumor formation
Phase zero drug testing in pancreatic adenocarcinoma
The potential of tumorgrafts for pancreatic adenocarcinoma
Nanotechnology applications for pancreatic ductal adenocarcinoma
Pancreatic Inflammation and Carcinogenesis - Constantinos Zambirinis and George Miller,New York University
DISEASES OF THE PANCREAS ACUTE PANCREATITIS Section Editor Markus M. Lerch and Marc Basselink
Gallstone-Related Pathogenesis of Acute Pancreatitis - Markus M Lerch and Ali Aghdassi, Greifswald, Germany Alcohol-Related Mechanisms of Acute Pancreatitis: The Roles of Mitochondrial Dysfunction and Endoplasmic Reticulum Stress - David Criddle, Richard Waldron, Aurelia Lugea and Stephen Pandol, University of Liverpool, UK and Cedars-Sinai Medical Center Los Angeles, CA Genetics of Acute Pancreatitis - F. Ulrich Weiss and Markus M. Lerch, Greifswald, Germany Relationship between Obesity and Pancreatitis - Sarah Navina, Clin-Path Associates, Tempe AZ and Vijay P. Singh, Mayo Clinic, Scottsdale AZ Drug-induced Acute Pancreatitis - Maria Christina Conti Bellocchi, Pietro Campagnola and Luca Frulloni, University of Verona, Italy Laboratory Diagnosis of Acute Pancreatitis and its severity
Imaging Assessment of Etiology and Severity of Pancreatitis - Thomas Bollen, Nimegen, The Netherlands Classification Systems for the Severity of Acute Pancreatitis - Rupjyoti Talukdar, Hyderabad, India and Santhi Vege, Mayo Clinic, Rochester Fluid resuscitation in acute pancreatitis - Georg Beyer, Julia Mayerle, Peter Simon and Markus M. Lerch, Greifswald Germany Pain Management in Acute Pancreatitis - Stephan Schorn, Güralp Ceyhan, Elke Tieftrunk, Helmut Friess, Ihsan Ekin Demir, Technical University Munich, Germany Prophylaxis and treatment withAntibiotic and Probiotics in Acute Pancreatitis - Marc G. Besselink, Amsterdam, The Netherlands
Role of Enteral and Parenteral Nutrition - Vinciane Rebours, Hospital Beaujon and INSERM UMR1149, Clichy, France Endoscopic Treatment of Infected Necrosis - Hjalmar C van Santvoort, Utrecht, The Netherlands and Martin Freeman, Minneapolis, USA Treatment of pancreatic necrosis – the Multimodal Glasgow Algorithm - Ross Carter, Euan J Dickson and Colin J McKay, Glasgow Royal Infirmary, UK Endoscopic assessment and treatment of biliary pancreatitis - Nora Hallensleben, Nicolien J. Schepers, Marco J Bruno, and Djuna L.Cahen, Rotterdam, The Netherlands Timing of Cholecystectomy after Acute Biliary Pancreatitis - Stefan A Bouwense, Mark van Baal, David da Costa and Marc Besselink, The Netherlands Management of Abdominal Compartment Syndrome in Acute Pancreatitis - Jan De Waele, Ghent, Belgium Prevention of ERCP-induced Pancreatitis - B. Josef Elmunzer, Medical University of South Carolina, Charleston Timing of Oral Refeeding after Acute Pancreatitis - Simone Gartner, Antje Steveling and Peter Simon, Griefswald, Germany
AUTOIMMUNE PANCREATITIS Section Editors Suresh T. Chari and Phil A. Hart
Evolution of the Concept of Autoimmune Pancreatitis and Its Subtypes - Daniel Longnecker, Geisel School of Medicine at Dartmouth, NH Diagnosis of Autoimmune Pancreatitis - Phil A Hart & Suresh T Chari, Mayo Clinic Rochester, MN Histology of Autoimmune Pancreatitis - Kenji Notahara & Lizhi Zhang, Kurashiki Central Hospital, Japan & Mayo Clinic, Rochester Serologic Abnormalities in Autoimmune Pancreatitis - Kazuichi Okazaki & Kazushige Uchida, Kansai Medical University, Japan CT and MR features of Autoimmune Pancreatitis - Naoki Takahashi, Mayo Clinic Rochester, MN ERCP Features of Autoimmune Pancreatitis - Terumi Kamisawa, Tokyo Metropolitan Hospital, Japan EUS in the Diagnosis of Autoimmune Pancreatitis - Larissa L Fujii & Michael J Levy, Mayo Clinic Rochester, MN Extra-pancreatic Features of Autoimmune Pancreatitis - John H. Stone, Harvard Medical School, Boston, MA Steroid Therapy in the Management of Autoimmune Pancreatitis - Tae Jun Song & Myung-Hwan Kim, Inje University College of Medicine & University of Ulsan College of Medicine, South Korea Immunomodulators and Rituximab in the Management of Autoimmune Pancreatitis - Phil A Hart & Suresh T Chari, Mayo Clinic Rochester Prognosis and Long Term Outcomes of Autoimmune Pancreatitis - Shigeyuki Kawa, Masahiro Maruyama & Takayuki Watanabe, Shinshu University School of Medicine, Japan Type 2 Autoimmune Pancreatitis - Gunter Kloppel, Technical University of Munich, Germany
CHRONIC PANCREATITIS Section Editors Julia Mayerle and Pramod Garg
Epidemiology of Chronic Pancreatitis - Jorge D Machicado, Vinciane Rebours and Dhiraj Yadav, Pittsburgh PA and Clichy,France Pancreatic Fibrosis - Shin Hamada, Atsushi Masamune and Tooru Shimosigawa, Tohoku University, Sendai, Japan Pathogenesis of Chronic Pancreatitis - Ali A. Aghdassi, University of Greifswald, Germany Natural Course of Chronic Pancreatitis - Paul Lankisch and Al Lowenfels, Luneburg, Germany and Valhalla, NY, Recurrent Acute Pancreatitis and Progression to Chronic Pancreatitis - Nalini M. Guda and Camilla Nøjgaard, Milwaukee WI and Copenhagen, Denmark Clinical and Laboratory Diagnosis of Chronic Pancreatitis - Matthias Loehr, Stockholm, Sweden Hereditary Pancreatitis - Celeste A. Shelton and David Whitcomb, University of Pittsburgh, Pittsburgh, PA Idiopathic Chronic Pancreatitis: Genetic Predisposition - Pramod Kumar Garg and Atsushi Masamune, New Delhi, India and Sendai, Japan Pathogenesis and Treatment of Pain in Chronic Pancreatitis - Søren Schou Olesen, Elke Tieftrunk, Güralp Ceyhan and Asbjörn Drewes Imaging in Chronic Pancreatitis - Raju Sharma and Devasenathipathy Kandasamy, All India Institute of Medical Science, New Delhi, India Endoscopic Ultrasound for the Diagnosis of Chronic Pancreatitis - Jintao Guo and Siyu Sun, Shenyang, China Conservative Therapy of Chronic Pancreatitis - Joachim Mössner, Leipzig, Germany Micronutrient ('Antioxidant') Therapy for Chronic Pancreatitis: Basis and Clinical Experience - Joan Braganza, Manchester, UK Diagnosis of pancreatic exocrine insufficiency in chronic pancreatitis - Jutta Keller and Peter Layer, Hamburg, Germany Interventional and Endoscopic Therapy of Chronic Pancreatitis - Julia Mayerle and Nageshwar Reddy Current Surgical Treatment Options in Chronic Pancreatitis - Jan D'Haese, Djuna Cahen and Jens Werner, Munich Germany and Rotterdam, the Netherlands Total Pancreatectomy and Islet Auto Transplantation for Chronic Pancreatitis - Sydne Muratore, Martin Freeman, and Greg Beilman, Minneapolis, MN Management of Endocrine Failure in Chronic Pancreatitis - Dana Andersen, NIH, Bethesda MD Pharmaceutical Developments for Chronic pancreatitis: Pipelines and Future Options - Rajarshi Mukherjee and Robert Sutton, Liverpool, UK
PANCREATIC ADENOCARCINOMA
Identifying Biomarkers to Diagnose and Follow Pancreatic Cancer
Imaging Techniques to Diagnose Pancreatic Cancer
Epidemiology of Pancreatic Cancer
Pathology of Exocrine Pancreatic Tumors
Surgical Treatment of Pancreatic Cancer
Primary Chemotherapy
The Role of aduvant therapy for Pancreatic Cancer
OTHER PANCREATIC NEOPLASMS Section Editor Carlos Fernandez Del Castillo DIABETES AND OBESITY Section Editor Dana Andersen HEREDITARY DISEASES OF THE PANCREAS Section Editors David Whitcomb and Mark Lowe
Cystic Fibrosis
Shwachman Diamond Syndrome
Hereditary Pancreatitis
Familial Pancreatic Cancer
Testing for genetic risk factors
