Molecules

This section includes short articles on molecules present in and relevant to the function of exocrine pancreatic cells. The long term goal is to create a parts list for each major cell type. Each entry will include:

1. A general description of the structure and function of the molecule with references to review articles, seminal papers and links to NCBI.

2. Information on the specific function of the molecule in the pancreas including its subcellular localization. References will be as inclusive as possible for all work on this molecule in the pancreas.

3. Tools for the study of this molecule including antibodies, viral vectors and transgenic mice will be listed with emphasis on those confirmed by the author or community members. Links to methods are included when appropriate.

Molecule pages can be accessed by the search function, alphabetic listing below, or by links embedded in other sections of the web site.

We invite members of the pancreas research community to volunteer to write Molecule Pages for molecules that you have interest and expertise in. Please contact one of the Editors for approval and assignment. Instructions for preparing molecule pages can be found here.

Newest Molecules

Title Post date Author
Inositol 1,4,5-trisphosphate receptors (InsP3R) October 19, 2017 David Yule
Amylase April 24, 2017 John A. Williams
Rab1 February 25, 2016 John A. Williams
GP-2 December 9, 2015 John A. Williams
Somatostatin November 23, 2015 Jean Morisset
Galanin June 27, 2015 Savio George Barreto
Rab27 April 24, 2015 Yanan Hou
Bombesin March 13, 2015 John A. Williams
Caerulein December 23, 2014 John A. Williams
Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) October 29, 2014 Deepinder Goyal

A

  • ADAM10
  • Actin
  • ADMR
  • Adrenomedulin
  • AGR2
  • Akt
  • Alpha catenin
  • Alpha smooth muscle actin
  • AMPK
  • Amylase
  • Angiotensin
  • Angiotensin R type 1
  • Aquaporins
  • ASK
  • ATDC
  • ATF2
  • ATF3
  • ATF4
  • ATF6
  • Atg5
  • Axl

B

  • Bcl-2
  • Beclin 1
  • Beta actin
  • Beta catenin
  • Beta PIX
  • BiP (GRP78)
  • Bombesin
  • Bombesin receptor
  • B-Raf

C

  • CA19-9
  • CaCCs
  • Caerulein
  • Calcineurin
  • Calmodulin
  • CaM kinase II
  • CaM kinase III
  • CaM kinase IV
  • cAMP
  • Calnexin
  • Calreticulin
  • Carboxypeptidase
  • Caspase-3
  • Caspase-8
  • Caspase-9
  • Caspase-12
  • Cathepsin B
  • Cathepsin L
  • CCK
  • CCKR1 (CCK-A receptor)
  • CCKR2 (CCK-B receptor)
  • Cdc42
  • CEACAM1
  • CFTR
  • CGRP
  • Chloride-bicarbonate exchanger
  • Cholesterolesterase
  • CHOP (GADD153)
  • Chymase
  • Chymotrypsinogen
  • ClC-2
  • p21-Cip1
  • Claudin
  • CLCA1/2
  • Cofilin
  • Co-lipase
  • Collagen
  • Complexin 2
  • Connexins
  • Cortactin
  • COX-2
  • Creb
  • CRHSP-24
  • CRHSP-28
  • c-Raf1
  • CRKII
  • CSL transcription complex
  • CUX1
  • Cyclic ADP-ribose (cADPR)
  • Cyclin A
  • Cyclin B
  • Cyclin D
  • Cyclin E
  • Cysteine string protein

D

  • DCAMKL-1
  • Diacylglycerol (DAG)
  • Diacylglycerol kinase
  • Deoxyribonuclease
  • Desmin
  • Dynactin
  • Dynein

E

  • E-cadherin
  • EDEM1
  • EGF
  • EGFR
  • eEF2
  • eIF2
  • eIF2B
  • eIF4F
  • Elastase (proelastase)
  • Elk1
  • EPAC
  • ErbB2 (HER2)
  • ErbB4
  • ERdj4
  • ERK1/2
  • ERK5
  • Ero1
  • ERp57
  • Estrogen receptor
  • Ezrin

F

  • Fak
  • FGF
  • FGF21
  • FGF receptors
  • FKBP-12
  • Flk-1
  • Flt-1
  • Fos (cFos, FosB)
  • Fyn

G

  • Gab1
  • GADD34
  • Galanin
  • Gamma glutamyl transpeptidase
  • Gamma secretase
  • Galpha q/11
  • Galpha s
  • Galpha i
  • Galpha 12/13
  • GAPDH
  • Gastrin
  • Gata-4
  • Gli
  • GLP-1
  • Glucagon
  • Glucocorticoid receptor
  • Glucosidase I,II
  • GM130
  • cGMP
  • GP-2
  • GP-3
  • Grb2
  • GRP94
  • GRP170 (Orp150)
  • GSK3
  • Guanylate cyclase

H

  • Hedgehog ligands (Sonic, Indian, Desert)
  • Heparin binding EGF
  • Hepatocyte growth factor
  • Hepatocyte nuclear factor (HNF)-4
  • Hepatocyte nuclear factor (HNF)-6
  • Hes
  • Hey
  • Hif-1α
  • H-K ATPase (gastric)
  • HSP27
  • HSP70
  • HSP90
  • Hydrogen sulfide

I

J

  • Jak2
  • JMV-180
  • Jnk
  • Jun (cJun)
  • JunB

K

  • KCNQ1
  • Keratin
  • Kinesin
  • p27KIP1

L

  • LAMP-1
  • Lamp2
  • LC3
  • LARG
  • Lyn

M

  • M3 muscarinic receptor
  • MAPKAPK-2
  • MARCKS
  • MCP-1
  • MEFs
  • MEKK1
  • Metallothionine
  • Mist1
  • MLCK
  • MLK
  • MMPs
  • P38 MAPK
  • Myosin I
  • Myosin II
  • Myosin V

N

O

  • Occludin
  • Orai

P

  • p53
  • PACAP
  • PAK2
  • pancreastatin
  • Pancreatic Polypeptide
  • PAP1 / RegIII
  • Par2
  • Patched
  • Paxillin
  • PCNA
  • PDI
  • Pdx1
  • PERK
  • Phosphoinositides
  • Phosphotidylcholine
  • PI3K
  • PKA
  • PKC
  • PLA2
  • PLC
  • PLD
  • Plaxoglobin
  • PLRP1
  • PLRP2
  • PMCA
  • PPARgamma
  • PpiB
  • Presenilin
  • PSTI
  • Ptf1a
  • Pyk2
  • PYY

Q-R

S

  • S100P
  • SCAMPS
  • Sdmg1
  • Secretin
  • Secretin receptor
  • SEK
  • SEL1L
  • SERCA
  • Sec61
  • Sec63
  • Shc
  • SHP-1
  • Signal peptidase
  • Signal peptide receptor
  • SIL1 (Bap)
  • p70 S6K
  • p90 S6K
  • Smad
  • Smoothened
  • SNAP-23, -29
  • Sodium-bicarbonate cotransporter
  • Sodium-hydrogen exchanger
  • Sodium-potassium ATPase
  • Soluble adenylyl cyclase
  • Somatostatin
  • Somatostatin receptors
  • Sos
  • SPCA2
  • Src
  • Stanniocalcin2
  • Stat3
  • Stat5
  • Stim1/2
  • Substance P (SP)
  • Syk
  • Synaptotagmin
  • Syncollin
  • Syntaxin

T

U-W

  • Vacuolar ATPase
  • VAMP2
  • VAMP8
  • VEGF
  • VIP
  • VMP1
  • VPAC receptors

X-Z