Pathway Type:
Signaling
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Figure contributed by Maria Eugenia Sabbatini
Reviews
- Role of cyclic AMP in the regulation of acinar and duct cell function
Components
- Secretin
- Secretin receptor
- VIP
- VPAC receptors
- CCK
- CCK receptors
- Somatostatin
- Somatostatin receptors
- RGS proteins
- Galpha s
- Galpha i
- Transmembrane adenylyl cyclase
- Soluble adenylyl cyclase
- Cyclic nucleotide phosphodiesterase (PDE)
- PKA
- AKAP
- PKI
- EPAC
- Rap1
- Rap1GAP
- Creb
- CFTR
- InsP3 receptors
Methods
- Measurement of cAMP and adenylate cyclase
- Monitoring of intracellular pH and H+ fluxes in duct cells