Spink3 KO - Tg Psti1

Full name (if applicable): 


B6.Spink3-/- -Tg(Cela-Spink3)#Rali


Obtained from mating Spink+/- with Tg(Psti1) and subsequently Spink-/--Tg(Psti1) males with Spink-/--Tg(Psti1) females.

Model type: 

-          Spink-/-: was derived from gene targeting in mouse embryonic stem cells by insertion of a PGK-neo cassette in exon 1 in front of the initiation codon.  Spink-/- is not viable; mice die before 1 week of age.

-          Tg(Psti1) also known as Tg(Cela1-Spink3)#Rali rescues the Spink-/- phenotype.  The Spink-/--Tg(Psti1) have normal phenotype.

Genetic background: 



Romac JM, Ohmuraya M, Bittner C, Majeed MF, Vigna SR, Que J, Fee BE, Wartmann T, Yamamura K, Liddle RA.

Am J Physiol Gastrointest Liver Physiol. 2010 Apr;298(4):G518-24. Epub 2010 Jan 28.


Produced by submitter who can be contacted to obtain the mice.

Joelle Romac or Rodger Liddle