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Figure prepared by R. Alberto Travagli and Kirsteen Browning
Reviews
- Neural control of the pancreas
- Neuropeptides and pancreatic secretion
- Muscarinic cholinergic receptors and acinar secretion
- Pathways mediating pancreatic pain
Components
- GRP
- GRP receptors
- Muscarinic cholinergic receptors
- Nicotinic cholinergic receptors
- PACAP
- VIP
- VPAC receptors
- Tachykinin receptors
Methods
- Preparation of pancreatic fragments for studying the role of nerves and islets on pancreatic exocrine secretion Savio G Barretto and Gino TP Saccone
- Measurement of muscarinic receptors and their properties on acinar cells
- An isolated rat pancreas preparation for studying pancreatic spinal mechanosensitive and chemosensitive afferent activity Ann C Schloithe, C M Woods and Gino TP Saccone
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Comments
Missing the Area Postrema (AP) in the brainstem
A critical component of pancreatic regulation is the “endoneurocrine” feedback system. The AP is immendiately adjacent to, and cross-innervating the NTS. The AP has a fenistrated blood-brain barrier (BBB) which allows regulatory peptides to directly modulate pancreatic secreation thorough inhibiting both vago-vagal reflexes, and from centeral sites. We have publsihed extensively on this - see the references below.Whitcomb DC, Taylor IL, Vigna SR. Characterization of saturable binding sites for circulating pancreatic polypeptide in rat brain. Am J Physiol. 1990;259:G687-G91 Hernandez EJ, Whitcomb DC, Vigna SR, Taylor IL. Saturable binding of circulating peptide YY in the dorsal vagal complex of rats. Am J Physiol. 1994;266(3 Pt 1):G511-6 Deng X, Guarita D, Pedroso M, Kreiss C, Wood P, Sved A, et al. PYY inhibits CCK stimulated pancreatic secretion through the area postrema in unanesthetized rats. Am J Physiol Regul Integr Comp Physiol. 2001;281(2):R645-53.